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The 21st century India is still battling with issues of accessibility, affordability and availability of quality health to masses. It is also facing a myriad of challenges and opportunities for development of indigenous, low cost, and accessible technologies with the influence from cultural diversity, demographic dividend and geographical segmentation leading to varied needs as per the regional conditions of climate, disease prevalence, nutrition and sanitation. Affordable innovative solutions are to be generated and translated to resolve various health issues of diverse India. To understand country's need for attainment of the holistic slogan of 'health for all', a regional (East-West- North-South) analysis was conducted based on the state-level disease burden report 2017. Then the entire translation ecosystem was summarized detailing significance of each stakeholder and regional health-care translation strength to project translation scenario of the country. This paper has emphasized on the essentiality to strengthen translation capacity of each region to meet diverse health-care needs of the people. It has proposed to establish a robust translation ecosystem for innovative indigenous medical technologies by adopting regional establishment of technology transfer entities with focused translation as per the needs of a particular region. [ABSTRACT FROM AUTHOR]