1. Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes with Olefins in Water
- Author
-
E. Ramesh, Kallol Mukherjee, Akhila K. Sahoo, and Koushik Ghosh
- Subjects
Aqueous medium ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Ruthenium ,Catalysis ,chemistry.chemical_compound ,Amide ,Intramolecular force ,Reactivity (chemistry) - Abstract
A Ru-catalyzed intramolecular hydroarylation of arenes in an aqueous medium is presented herein. With the aid of methyl phenyl sulfoximine or an amide directing group, this atom-efficient hydroarylation of arenes ensued dihydrobenzofuran derivatives. Sequential double hydroarylation of arene motifs resulted in highly peripheral-decorated heterocycles. Deuterium labeling studies and control experiments offer valuable information in understanding the reactivity and the mechanistic data.
- Published
- 2018