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Start Over Author "Huixin Wang" Journal asian journal of pharmaceutical sciences
2 results on '"Huixin Wang"'

1. A systematic in vitro investigation on poly-arginine modified nanostructured lipid carrier: Pharmaceutical characteristics, cellular uptake, mechanisms and cytotoxicity

Author

Mingshuang Sun, Yunyun Gao, Zhihong Zhu, Huixin Wang, Cuiyan Han, Xinggang Yang, and Weisan Pan

Subjects
Poly-arginine, NLC, Cellular uptake, Mechanisms, Cytotoxicity, Therapeutics. Pharmacology, RM1-950
Abstract

The aim of the present study was to develop a poly-arginine modified nanostructured lipid carrier (R-NLC) by fusion-emulsification method and to test its pharmaceutical characteristics. The influence of R-NLC on A549 cells like cellular uptake and cytotoxicity was also appraised using unmodified NLC as the controlled group. As the results revealed, R-NLC had an average diameter of about 40 nm and a positive zeta potential of about +17 mv, the entrapment efficiency decreased apparently, and no significant difference on the in vitro drug release was found after R8-modification. The cellular uptake and cytotoxicity increased obviously compared with unmodified NLC. The cellular uptake mechanisms of R-NLC involved energy, macropinocytosis, clathrin-mediated endocytosis, and caveolin-mediated endocytosis. The outcomes of the present study strongly support the theory that cell penetrating peptides have the ability of enhancing the cellular uptake of nanocarriers.

Published
2017
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2. A systematic in vitro investigation on poly-arginine modified nanostructured lipid carrier: Pharmaceutical characteristics, cellular uptake, mechanisms and cytotoxicity

Author

Yunyun Gao, Mingshuang Sun, Huixin Wang, Cuiyan Han, Weisan Pan, Zhihong Zhu, and Xinggang Yang

Subjects
0301 basic medicine, Cytotoxicity, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, Cell, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Pharmaceutical Science, 02 engineering and technology, Endocytosis, ComputingMethodologies_ARTIFICIALINTELLIGENCE, 03 medical and health sciences, Cellular uptake, Mechanisms, Zeta potential, medicine, Original Research Article, Poly-arginine, ComputingMethodologies_COMPUTERGRAPHICS, Pharmacology, A549 cell, Chemistry, Pinocytosis, lcsh:RM1-950, 021001 nanoscience & nanotechnology, In vitro, ComputingMethodologies_PATTERNRECOGNITION, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, NLC, Nanocarriers, 0210 nano-technology
Abstract

Graphical Abstract Unlabelled image, The aim of the present study was to develop a poly-arginine modified nanostructured lipid carrier (R-NLC) by fusion-emulsification method and to test its pharmaceutical characteristics. The influence of R-NLC on A549 cells like cellular uptake and cytotoxicity was also appraised using unmodified NLC as the controlled group. As the results revealed, R-NLC had an average diameter of about 40 nm and a positive zeta potential of about +17 mv, the entrapment efficiency decreased apparently, and no significant difference on the in vitro drug release was found after R8-modification. The cellular uptake and cytotoxicity increased obviously compared with unmodified NLC. The cellular uptake mechanisms of R-NLC involved energy, macropinocytosis, clathrin-mediated endocytosis, and caveolin-mediated endocytosis. The outcomes of the present study strongly support the theory that cell penetrating peptides have the ability of enhancing the cellular uptake of nanocarriers.

Published
2017
Full Text
View/download PDF

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