1. XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Chinese Han Population: A Meta-analysis
- Author
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Quan-Dda Liu, Ti-ye Sun, Jun-gui Liu, Weihong Duan, Yu Xie, Ning-xin Zhou, Jun-zhou Chen, Zhen-Yu Zhu, Ze-Feng Gao, and Mao-Sheng Dong
- Subjects
Oncology ,China ,Cancer Research ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Epidemiology ,Xrcc1 arg399gln ,Bioinformatics ,Polymorphism, Single Nucleotide ,Chinese han population ,Asian People ,Risk Factors ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,business.industry ,Liver Neoplasms ,Public Health, Environmental and Occupational Health ,Case-control study ,Increased hepatocellular carcinoma risk ,Knowledge infrastructure ,medicine.disease ,DNA-Binding Proteins ,X-ray Repair Cross Complementing Protein 1 ,Case-Control Studies ,Hepatocellular carcinoma ,Meta-analysis ,Gene polymorphism ,business - Abstract
Purpose: Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent. We therefore here examined whether the XRCC1 Arg399Gln gene polymorphism confers hepatocellular carcinoma risk by conducting a meta-analysis. Methods: PubMed, Google scholar and China National Knowledge Infrastructure databases were searched for eligible articles in English and Chinese that were published before April 2012. Results: 6 studies involving 1,246 patients with hepatocellular carcinoma and 1,953 controls were included. The association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma in the Chinese Han population was significant under GG vs AA (OR = 1.48, 95% CI = 1.13 to 1.94). Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. Conclusions: In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
- Published
- 2012