1. Prognostic implications for high expression of MiR-25 in lung adenocarcinomas of female non-smokers.
- Author
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Xu FX, Su YL, Zhang H, Kong JY, Yu H, and Qian BY
- Subjects
- Adenocarcinoma mortality, Adenocarcinoma of Lung, Biomarkers, Tumor genetics, Carcinoma, Non-Small-Cell Lung mortality, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms mortality, Lymphatic Metastasis genetics, MicroRNAs genetics, Middle Aged, Multivariate Analysis, Neoplasm Staging, Smoking genetics, Adenocarcinoma genetics, Carcinoma, Non-Small-Cell Lung genetics, Lung Neoplasms genetics, MicroRNAs biosynthesis
- Abstract
Background: Adenocarcinoma (ADC) is the most common histological type of lung cancer and its proportion is rising, especially in Asian non-smoking women. Recent studies suggest miR-25 may have diverse effects on the pathogenesis of different types of cancer. However, the role of miR-25 in lung cancer is still unknown. The aim of this study was to investigate the potential clinical value of miR-25 in non-smoking women with lung ADC., Patients and Methods: Quantitative RT-PCR was performed to evaluate the expression of miR-25 in 100 lung ADC tumor tissues and matched plasma samples and Pearson correlation tests were used to analyze the relationship between values. Associations of miR-25 expression with clinicopathological features were determined using the Student's t-test. To determine prognostic value, overall survival (OS) was evaluated using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazard model., Results: Expression of miR-25 in tissue was found to be associated with lymph node metastasis (P=0.021) and disease stage (P=0.012). Moreover, high miR-25 expression was also associated with poorer overall survival of women with lung ADC (P=0.008)., Conclusion: Tissue miR-25 expression may be associated with tumor progression and have prognostic implications in female lung ADC patients.
- Published
- 2014
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