1. Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract
- Author
-
Baskar Lakshmanan, Simon Santosh Jena, Nagaraj Selvaraj, Muthukumar Karuppasamy, Ashok Kumar Pattnaik, and Papiya Mitra Mazumder
- Subjects
Antifungal Agents ,Rubiaceae ,Antimicrobial activity ,Plant Roots ,Griseofulvin ,Enterococcus faecalis ,Tensile strength ,Ixora coccinea ,chemistry.chemical_compound ,Ciprofloxacin ,Animals ,Rats, Wistar ,Candida albicans ,Medicine(all) ,Wound Healing ,Nitrofurazone ,biology ,Traditional medicine ,integumentary system ,Plant Extracts ,Bacterial Infections ,General Medicine ,biology.organism_classification ,Antimicrobial ,Anti-Bacterial Agents ,Rats ,Wound contraction ,Ethanolic extract ,Disease Models, Animal ,Chloramphenicol ,Mycoses ,chemistry ,Antibacterial activity ,Wound healing ,Phytotherapy - Abstract
ObjectiveTo evaluate the wound healing and antimicrobial activity of root extracts of Ixora coccinea (I. coccinea).MethodsTo investigate the wound healing efficacy of root extract of I. coccinea Linn, five groups of animals were divided each containing six animals. Two wound models including incision and excision wound models were used in this study. The parameters studied were tensile strength on incision wound model and in terms of wound contraction for excision wound model were compared with standard Nitrofurazone (NFZ) ointment (0.2% w/w). Six extracts (ethanol, aqueous, petroleum ether, benzene, chloroform and ethyl acetate) of I. coccinea were screened for in vitro growth inhibiting activity against different bacterial strains viz, Staphylococcus aureus, Bacillus pumilius, Enterococcus faecalis, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa and fungi Candida albicans and Aspergillus niger were compared with the standard drugs ciprofloxacin and chloramphenicol for antibacterial and griseofulvin for antifungal screening. The serial dilution and cup (or) well plate methods were used for the antimicrobial study and MIC was determined.ResultsThe ethanolic extract showed significant (P
- Published
- 2011
- Full Text
- View/download PDF