1. Enhanced Transmucosal Transport Using Osmolyte-Mediated Fluid-Matrix Interaction
- Author
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Yeo Yoon, Ka Yaw Teo, Bumsoo Han, Seungman Park, and Basma M. Ibrahim
- Subjects
Materials science ,Osmolyte ,Drug delivery ,respiratory system ,Matrix (biology) ,Oral cavity ,Polymeric nanoparticles ,Mucus ,Biomedical engineering - Abstract
Various drug delivery systems are developed to deliver therapeutic and diagnostic agents to tissues covered with mucus, such as airways, nasal cavity, or oral cavity [1]. However, the mucus, which present for protection of the tissues, significantly hinders the transport of these agents and ultimately mitigates their efficacy [2]. Several studies have been performed to improve the transmucosal transport by studying the transport rates of polymeric nanoparticles with various sizes and surface chemistry [3–5]. However, drug delivery systems with improved transmucosal transport capability are still highly desired.Copyright © 2011 by ASME
- Published
- 2011
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