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3. Effects of an isoenergetic multifactorial diet on pancreatic fat and insulin secretion in patients with type 2 diabetes: A randomized controlled trial

Author

Della Pepa, G., primary, Costabile, G., additional, Salamone, D., additional, Brancato, V., additional, Monti, S., additional, Salvatore, M., additional, Cipriano, P., additional, Vitale, M., additional, Riccardi, G., additional, Rivellese, A.A., additional, Annuzzi, G., additional, and Bozzetto, L., additional

Published
2022
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5. Treating Non-Alcoholic Fatty Liver Disease In Patients With Type 2 Diabetes By Targeting Multiple Dietary Components: The Portfolio Diet

Author

Della Pepa, G., primary, Monti, S., additional, Vetrani, C., additional, Vitale, M., additional, Izzo, A., additional, Lombardi, G., additional, Salamone, D., additional, Fusco, A., additional, Tommasone, M., additional, Clemente, G., additional, Bozzetto, L., additional, Annuzzi, G., additional, Mancini, M., additional, Mirabelli, P., additional, Salvatore, M., additional, Riccardi, G., additional, and Rivellese, A.A., additional

Published
2019
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9. Diets naturally-rich in polyphenols improve glucose metabolism in people at high cardiovascular risk: A controlled randomized trial

Author

Bozzetto, L., primary, Annuzzi, G., additional, Pacini, G., additional, Vetrani, C., additional, Costabile, G., additional, Mangione, A., additional, Della Pepa, G., additional, Cocozza, S., additional, Griffo, E., additional, Anniballi, G., additional, Tura, A., additional, Giacco, A., additional, Riccardi, G., additional, and Rivellese, A.A., additional

Published
2014
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10. Ezetimibe beneficially influences fasting and postprandial triglyceride-rich lipoproteins in type 2 diabetes.

Author

Bozzetto L, Annuzzi G, Corte GD, Patti L, Cipriano P, Mangione A, Riccardi G, and Rivellese AA

Subjects
Blood Glucose metabolism, Centrifugation, Density Gradient, Cholesterol metabolism, Chylomicrons metabolism, Cross-Over Studies, Double-Blind Method, Ezetimibe, Fasting, Female, Humans, Male, Middle Aged, Placebos, Postprandial Period, Simvastatin administration & dosage, Time Factors, Anticholesteremic Agents pharmacology, Azetidines administration & dosage, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 drug therapy, Lipoproteins, VLDL blood, Triglycerides blood
Abstract

Introduction: Type 2 diabetes is associated with atherogenic abnormalities of postprandial triglyceride-rich lipoproteins. This study evaluated whether ezetimibe, by inhibiting intestinal cholesterol absorption, influences chylomicrons and VLDL particles at fasting and after a standard meal., Methods: By a double blind cross-over design 15 subjects with type 2 diabetes and hypercholesterolaemia followed in random order a 6-week treatment with ezetimibe 10mg+simvastatin 20 mg (EZE+S) or placebo+simvastatin 20 mg (P+S) and, after a 6-week wash-out period, crossed over to the other treatment (NCT00699023). At the end of each period lipids, apoB-48, and apoB-100 concentrations in plasma and lipoprotein fractions (separated by discontinuous density gradient ultracentrifugation) were determined before and over 6h following a high-fat test meal., Results: Compared with P+S, EZE+S induced, (a) beside a greater decrease in LDL cholesterol, (b) a significant decrease in chylomicron lipid content both at fasting and postprandially (4.4 ± 2.7 vs. 8.3 ± 8.7 mg/dl × 6 h total AUC for cholesterol, p < 0.05; 18 ± 12 vs. 29 ± 24 mg/dl triglyceride concentrations at 6h, p < 0.05), (c) a significant decrease in chylomicron postprandial apoB-48 (0.03 ± 0.03 vs. 0.09 ± 0.08 mg/l at 4 h, p < 0.05), and (d) significant fasting and postprandial decreases in the cholesterol content of VLDL, IDL, and LDL, as shown by the significant reduction of the cholesterol/triglyceride ratio in these lipoproteins., Conclusions: A 6-week treatment with ezetimibe and simvastatin, compared to simvastatin alone, positively influences lipoprotein profile both at fasting and postprandially in type 2 diabetic patients by favouring the production of cholesterol-poor chylomicrons and VLDL particles that have less atherogenic potential., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2011
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