1. Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains.
- Author
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Ronden JE, Groenen-van Dooren MM, Hornstra G, and Vermeer C
- Subjects
- Animals, Diet, Dietary Fats, Unsaturated administration & dosage, Dietary Fats, Unsaturated pharmacology, Dietary Fats, Unsaturated therapeutic use, Disease Models, Animal, Disease Susceptibility, Diterpenes pharmacology, Diterpenes therapeutic use, Dose-Response Relationship, Drug, Male, Phytol pharmacology, Phytol therapeutic use, Rats, Rats, Wistar, Thrombosis blood, Vitamin K administration & dosage, Vitamin K analogs & derivatives, Vitamin K chemistry, Vitamin K pharmacology, Vitamin K toxicity, Vitamin K 1 pharmacology, Vitamin K 2 analogs & derivatives, Vitamin K Deficiency complications, Blood Coagulation drug effects, Platelet Aggregation drug effects, Thrombosis prevention & control, Vitamin K therapeutic use
- Abstract
Vitamin K is involved in the biosynthesis of a number of blood coagulation factors and bone proteins. It has been suggested that the vitamin K requirement of bone tissue is higher than that of the liver. Here we report that in rats very high doses of vitamin K affected neither the blood coagulation characteristics nor the blood platelet aggregation rate. This was observed for both phylloquinone and menaquinone-4. Both vitamers were also tested for their effects on the arterial thrombosis tendency in the rat aorta loop model. The mean obstruction times were prolonged at a high intake of menaquinone-4 (250 mg/kg body weight/day), and shortened after a similarly high phylloquinone regimen. Since (a) both vitamers only differ in their aliphatic side chains; and (b) a similar trend was observed after administration of phytol and geranylgeraniol, we conclude that the modulation of the arterial thrombosis tendency is accomplished by the side chain of vitamin K.
- Published
- 1997
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