1. Active matrix metalloproteinases 3 and 9 are independently associated with coronary artery in-stent restenosis
- Author
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L.V. Phillips, Gerard T. Wilkins, Gregory T. Jones, A.M. van Rij, Gregory P. Tarr, and Michael J.A. Williams
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Enzyme-Linked Immunosorbent Assay ,Coronary Artery Disease ,Matrix metalloproteinase ,Coronary Angiography ,Prosthesis Design ,Risk Assessment ,Gastroenterology ,Coronary Restenosis ,Restenosis ,Risk Factors ,Internal medicine ,Coronary stent ,Odds Ratio ,Humans ,Medicine ,Angioplasty, Balloon, Coronary ,Aged ,Tissue Inhibitor of Metalloproteinase-1 ,business.industry ,Vascular disease ,Stent ,Odds ratio ,Middle Aged ,medicine.disease ,Enzyme Activation ,Treatment Outcome ,medicine.anatomical_structure ,Matrix Metalloproteinase 9 ,ROC Curve ,Metals ,Area Under Curve ,Case-Control Studies ,Cardiology ,Matrix Metalloproteinase 2 ,Female ,Matrix Metalloproteinase 3 ,Stents ,In stent restenosis ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,New Zealand ,Artery - Abstract
This study aimed to determine whether plasma levels of active matrix metalloproteinases (MMP) are predictors of in-stent restenosis (ISR) in New Zealand patients treated with bare-metal coronary stents.A group of 152 patients with a history of ISR were compared with 151 symptom free 1-year post-stenting patients (non-ISR). Demographic and angiographic characteristics were collected. Plasma samples were analyzed for the active forms of MMP-1, -2, -3 and -9 as well as tissue inhibitor of metalloproteinases (TIMP-1) using ELISA-based isoform sensitive assays.Both active MMP-9 and active MMP-3 were independently associated with history of ISR. Elevated levels of both active MMP-3 and -9 had an adjusted odds ratio of 11.8 (95% CI: 4-35, p0.0001) for association with ISR, with 37% of ISR patients having such levels versus 11% on non-ISR. The addition of both of the MMP biomarkers significantly increased the area under the curve (AUC) of a receiver operator characteristic (ROC) analysis incorporating the significant demographic and angiographic variables (AUC 0.85 versus 0.78, p0.005).Measures of plasma active MMP isoforms appear to be independently associated with ISR, and assessment of multiple MMP markers yields cumulative utility.
- Published
- 2009
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