1. Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus
- Author
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Stefan Vöö, Gregory I. Giles, Johannes Waltenberger, Bevan P. Gang, Michael J. Davies, Kevin D. Croft, Naomi Stanley, Nadina Stadler, Vladimir Vacata, Trevor A. Mori, Mat J.A.P. Daemen, Sylvia Heeneman, Amsterdam Cardiovascular Sciences, Pathology, Pathologie, Cardiologie, Beeldvorming, and RS: CARIM School for Cardiovascular Diseases
- Subjects
Carotid Artery Diseases ,Male ,medicine.medical_specialty ,endocrine system diseases ,Metal ions in aqueous solution ,Iron ,chemistry.chemical_element ,Down-Regulation ,Zinc ,Type 2 diabetes ,Calcium ,Protein oxidation ,Mass Spectrometry ,Lipid oxidation ,Internal medicine ,Diabetes mellitus ,Oxidation ,medicine ,Humans ,Metal ions ,Netherlands ,F2-Isoprostanes ,Electron Spin Resonance Spectroscopy ,Type 2 Diabetes Mellitus ,medicine.disease ,Lipids ,Plaque, Atherosclerotic ,Endocrinology ,Carotid Arteries ,chemistry ,Biochemistry ,Diabetes Mellitus, Type 2 ,Microscopy, Fluorescence ,Metals ,Female ,Autopsy ,Cardiology and Cardiovascular Medicine ,Oxidation-Reduction ,Copper ,Diabetic Angiopathies - Abstract
Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P
- Published
- 2012
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