1. Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
- Author
-
Daniel H. O'Leary, Valerie L. Arends, Wendy S. Post, Donna K. Arnett, W. H. Linda Kao, David R. Jacobs, W. Craig Johnson, Richard A. Kronmal, Michael Y. Tsai, A. Richey Sharrett, and Nancy S. Jenny
- Subjects
Male ,medicine.medical_specialty ,Biology ,Asymptomatic ,Article ,Cohort Studies ,chemistry.chemical_compound ,High-density lipoprotein ,Risk Factors ,Internal medicine ,Genotype ,Cholesterylester transfer protein ,medicine ,Humans ,Alleles ,Subclinical infection ,Aged ,Aged, 80 and over ,Polymorphism, Genetic ,Cholesterol ,Genetic transfer ,Cholesterol, HDL ,Genetic Variation ,Middle Aged ,Atherosclerosis ,Cholesterol Ester Transfer Proteins ,Endocrinology ,chemistry ,Cardiovascular Diseases ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Lipoprotein - Abstract
The cholesteryl ester transport protein (CETP) plays a key role in high-density lipoprotein (HDL) metabolism. Genetic variants that alter CETP activity and concentration may cause significant alterations in HDL-cholesterol (HDL-C) concentration; however, controversies remain about whether these genetic variants are associated with atherosclerosis. We genotyped the CETP R451Q, A373P, -629C/A, Taq1B, and -2505C/A polymorphisms in a cohort of Caucasian, Chinese, African-American, and Hispanic individuals within the Multi-Ethnic Study of Atherosclerosis. Genotypes were examined in relationship to HDL-C, CETP activity, CETP concentration, and three measures of subclinical cardiovascular disease (CVD): coronary artery calcium (CAC) measured by fast CT scanning, and carotid intimal-medial thickness (IMT) and carotid artery plaque, measured by ultrasonography. Carriers of the 451Q and 373P alleles have significantly higher CETP concentration (22.4% and 19.5%, respectively; p
- Published
- 2007