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In recent years, global climate change causes more extreme precipitation events in Lancang-Mekong River Basin (Lancang-Mekong Basin). It leads to the increase of rainstorm and flood risk, which poses a threat to the flood control safety of Lancang-Mekong Basin. Based on the precipitation data of four global climate models of CMIP6, this paper selected six indexes, including PRCPTOT and R10, to study the change characteristics of the extreme precipitation indexes in the Lancang-Mekong Basin during 1980–2020 and predicted the development trend of the extreme precipitation indexes in the Lancang-Mekong Basin during 2021–2050. The results show that from 1980 to 2020, the extreme precipitation events in regions I and IV showed an increasing trend, while those in regions II and III showed a decreasing trend. From 2021 to 2050, the extreme precipitation events in all regions of the Lancang-Mekong River show an upward trend, and most indexes increased compared with the historical period. The extreme precipitation indexes in most regions increases the most under the scenario of SSP5-8.5, while the increase is small under the scenario of SSP2-4.5; The six extreme precipitation indexes selected in the paper can better reflect the trend of extreme precipitation events and floods. The trend of extreme precipitation indexes in the Lancang-Mekong River basin in the future is more significant, which indicates that it may be affected more frequently by extreme precipitation events and floods. [ABSTRACT FROM AUTHOR]