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Agricultural production across the African continent is subjected to various effects of climate variability. One of the main staple foods in Sub-Saharan Africa is maize. However, limited scientific research has recently focused on understanding the possible effects of hydro-climatic variability on maize production. The aim of the present work was to contribute to policy and climate adaptation, thus reducing the vulnerability of maize production to climate change over Equatorial Africa. This study firstly examined long-term trends of precipitation (PRE), soil moisture (SM), actual evapotranspiration (E), and potential evapotranspiration (Ep), as well as surface air temperatures, including the minimum (TMIN) and maximum (TMAX). Secondly, the relationship between maize production and these climate variables was quantified for 18 Equatorial African countries (EQCs) over 1980−2021. To assess the linear trends, Mann–Kendall and Sen's slope tests were used to quantify the magnitude of the hydro-climatic variable trends at the 5% significance level, and Pearson's correlation coefficient was used to evaluate the relation of these climate parameters with the maize production. The annual mean PRE declined at 0.03 mm day−110a−1. Other climate variables increased at different rates: SM at 0.02 mmday−110a−1, E at 0.03 mm day−110a−1, Ep at 0.02 mm day−1 10a−1, TMIN and TMAX at 0.01 °C day−110a−1. A regional analysis revealed heterogeneous significant wet–dry and warm–cool trends over the EQCs. While, spatially, dry and warm climates were observed in the central to eastern areas, wet and warm conditions dominated the western regions. Generally, the correlations of maize production with the E, Ep, TMAX, and TMIN were strong (r > 0.7) and positive, while moderate (r > 0.45) correlations of maize production with PRE and SM were obvious. These country-wide analyses highlight the significance of climate change policies and offer a scientific basis for designing tailored adaptation strategies in rainfed agricultural regions. [ABSTRACT FROM AUTHOR]