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In the present study, the Morrison double-moment cloud microphysics scheme including mass and droplet number concentration of water and ice clouds is implemented into the Chinese mesoscale version of the Global/Regional Assimilation and Prediction System (GRAPES_Meso). Sensitivity experiments of different cloud condensation nuclei (CCN) values are conducted to study the impacts of CCN on cloud microphysical processes and radiation processes in East China. The model evaluation shows that the simulated cloud liquid water path (CLWP) is consistent with that of the National Center for Environment Prediction (NCEP) reanalysis, and the cloud optical depth (COD) and effective radius of cloud water (Rc) are in agreement with those of the Moderate Resolution Imaging Spectroradiometer (MODIS) datasets both in regional distribution and magnitudes. These comparisons illustrate the effectiveness of the Morrison scheme for the cloud processes in East China. For the study period of 8 to 12 October 2017, the sensitivity experiments show that with initial CCN number concentration (CCN0) increasing from 10 to 3000 cm−3, the maximum value of daily average Rc decreases by about 63%, which leads to a decrease of cloud-rain conversion rate. Moreover, the maximum value of daily average mixing ratio of cloud water (qc) increases by 133%, the maximum value of daily average mixing ratio of rain (qr) decreases by 44%, and the maximum value of daily average CLWP and COD increase by 100% and 150%, respectively. This results in about 65% increasing of the maximum value of daily average cloud downward shortwave radiative forcing (CDSRF) when CCN0 increases from 10 cm−3 to 3000 cm−3. The study indicates the important impacts of CCN on cloud properties and radiation effects. [ABSTRACT FROM AUTHOR]