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Abstract: The potential adverse human health impacts of emissions from UK airports have become a significant issue of public concern. We produce an inventory of UK airport emissions – including emissions from aircraft landing and takeoff operations, aircraft auxiliary power units (APUs) and ground support equipment (GSE) – with quantified uncertainty. Emissions due to more than 95% of UK passenger enplanements are accounted for. We apply a multi-scale air quality modelling approach to assess the air quality impacts of UK airports. Using a concentration-response function we estimate that 110 (90% CI: 72–160) early deaths occur in the UK each year (based on 2005 data) due to UK airport emissions. We estimate that up to 65% of the health impacts of UK airports could be mitigated by desulphurising jet fuel, electrifying GSE, avoiding use of APUs and use of single engine taxiing. Two plans for the expansion of UK airport capacity are examined – expansion of London Heathrow and new hub airport in the Thames Estuary. Even if capacity is constrained, we find that the health impacts of UK airports still increases by 170% in 2030 due to an increasing and aging population, increasing emissions, and a changing atmosphere. We estimate that if Heathrow were to be expanded as per previous UK Government plans, UK-wide health impacts in 2030 would increase by 4% relative to the 2030 constrained case, but this increase could become a 48% reduction if emissions mitigation measures were employed. We calculate that 24% of UK-wide aviation-attributable early deaths could be avoided in 2030 if Heathrow were replaced by a new airport in Thames Estuary because the location is downwind of London, where this reduction occurs notwithstanding the increase in aircraft emissions. A Thames hub airport would (isolated from knock-on effects at other airports) cause 60–70% fewer early deaths than an expanded Heathrow, or 55–63% fewer early deaths than an unexpanded Heathrow. Finally, replacing Heathrow by a Thames Estuary airport combined with emissions mitigation measures would reduce UK-wide aviation-attributable early deaths by 56% in 2030 while increasing aircraft movements, which would represent aviation causing about the same level of adverse health impacts as today in absolute terms. We note that because aviation emissions are included in the EU Emissions Trading Scheme, all options are CO2-neutral in terms of direct emissions (but not climate-neutral). [Copyright &y& Elsevier]