1. The association between multiple pilomatrixomas and APC gene mutations
- Author
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Paul Stevenson, Karl Rodins, and Rachel Susman
- Subjects
0301 basic medicine ,biology ,Adenomatous polyposis coli ,Colorectal cancer ,business.industry ,Chromosome ,Dermatology ,Gene mutation ,medicine.disease ,Familial adenomatous polyposis ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Germline mutation ,030220 oncology & carcinogenesis ,biology.protein ,medicine ,Cancer research ,Tumour suppressor gene ,business - Abstract
Dear Editor, Familial adenomatous polyposis is an autosomal dominant disorder caused by a germline mutation of the tumour suppressor gene adenomatous polyposis coli (APC) located on chromosome 5q22.2. Familial adenomatous polyposis is characterized by the development of hundreds of polyps in the colorectum, typically beginning in the second or third decade of life and eventually progressing to colorectal cancer in nearly all individuals if left untreated.
- Published
- 2018
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