1. High expression of interleukine-1 receptor antagonist in rheumatoid arthritis: Association with IL1RN*2/2 genotype
- Author
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S. Ramírez-Pérez, U. De la Cruz-Mosso, J. Hernández-Bello, G. E. Martínez-Bonilla, M. G. Ramírez-Dueñas, A. L. Pereira-Suárez, I. Parra Rojas, E. Martínez-López, J. Macías-Barragán, and J. F. Muñoz-Valle
- Subjects
il-1ra ,rheumatoid arthritis ,expression ,il1rn vntr ,polymorphism ,Internal medicine ,RC31-1245 - Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra is an anti-inflammatory cytokine codified by IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in IL1RN gene has been associated with RA risk and regulation of IL-1Ra expression. In this study, we determined mRNA and protein expression of IL-1Ra in RA patients and control subjects (CS). This study included 85 RA patients classified according to the ACR/EULAR 2010 criteria and 67 CS. Polymerase chain reaction was used to identify IL1RN VNTR polymorphism, the expression of sIL-1Ra (secreted isoform) mRNA was determined by SYBR Green-based real time quantitave-PCR assay, and IL-1Ra soluble levels quantification was evaluated by ELISA test. RA patients had higher soluble levels of IL-1Ra than CS (p
- Published
- 2017
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