1. Differential effects of renal denervation on arterial baroreceptor function in Goldblatt hypertension model
- Author
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Juliana Garcia Cespedes, Ruy R. Campos, Gisele S. Lincevicius, Tales Lyra de Oliveira, Cássia T. Bergamaschi, Caroline Gusson Shimoura, and Erika E. Nishi
- Subjects
Male ,medicine.medical_specialty ,Baroreceptor ,Sympathetic Nervous System ,Action Potentials ,Blood Pressure ,Pressoreceptors ,030204 cardiovascular system & hematology ,Kidney ,Renovascular hypertension ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Basal (phylogenetics) ,0302 clinical medicine ,Heart Rate ,Ischemia ,Internal medicine ,Heart rate ,medicine ,Animals ,Rats, Wistar ,Denervation ,Vasomotor ,Endocrine and Autonomic Systems ,business.industry ,Baroreflex ,medicine.disease ,Disease Models, Animal ,Blood pressure ,medicine.anatomical_structure ,Hypertension, Renovascular ,Anesthesia ,Cardiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Sympathetic vasomotor activity is significantly increased in renovascular hypertension. Renal denervation (DnX) has emerged as a novel therapy for resistant hypertension to drug therapy. However, the underlying mechanisms regarding the reduction in blood pressure (BP) after DnX remain unclear. Thus, the aim of this study was to evaluate the effects of DnX of a clipped kidney on the baseline and baroreceptor reflex control of post-ganglionic sympathetic activity to the contralateral kidney (rSNA) and lumbar (lSNA) nerves in Goldblatt hypertensive rats (2K1C). Renal denervation of an ischaemic kidney (DxX - all visible bundles of nerves were dissected - 10% phenol) was performed 5weeks after clipping (gap width: 0.2mm). Ten days after DnX, BP was significantly reduced (16%) in the 2K1C compared with the undenervated 2K1C (p
- Published
- 2016