1. 4 The management of haemoglobinopathies
- Author
-
Beatrix Wonke and Sally C. Davies
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Bone marrow transplant ,Thalassaemia major ,business.industry ,Curative procedure ,Hematology ,Disease ,medicine.disease ,Sickle cell anemia ,surgical procedures, operative ,Hemoglobinopathy ,hemic and lymphatic diseases ,medicine ,cardiovascular diseases ,business ,Stroke - Abstract
Summary Sickle cell disease (SCD) and thalassaemia major are the most important syndromes of the haemoglobinopathies. Complications of SCD can be life threatening and include stroke, hyposplenism and vaso-occlusive crises.Treatment of SCD is generally supportive or by transfusion, hydroxyurea or bone marrow transplant (BMT). b Thalassaemia major is treated with transfusion and chelation for the resulting iron overload which is the cause of most morbidity, with BMT the only curative procedure. c 2002 Elsevier Science Ltd
- Published
- 1991