1. Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning
- Author
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Sean M. Davidson, Niall Burke, Jack M. J. Pickard, and Derek M. Yellon
- Subjects
0301 basic medicine ,Male ,Physiology ,Ischemia ,Myocardial Infarction ,Myocardial Reperfusion Injury ,Ischaemic preconditioning ,030204 cardiovascular system & hematology ,Pharmacology ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Physiology (medical) ,Muscarinic acetylcholine receptor ,parasitic diseases ,Medicine ,Animals ,cardiovascular diseases ,Cardioprotection ,Intrinsic cardiac nervous system ,business.industry ,Antagonist ,Muscarinic antagonist ,Heart ,Isolated Heart Preparation ,Original Contribution ,medicine.disease ,Acetylcholine ,Rats ,Atropine ,Disease Models, Animal ,030104 developmental biology ,chemistry ,Anesthesia ,Ischemic Preconditioning, Myocardial ,Hexamethonium ,Ganglia ,business ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
This study aimed to investigate the role of the intrinsic cardiac nervous system in the mechanism of classical myocardial ischaemic preconditioning (IPC). Isolated perfused rat hearts were subjected to 35-min regional ischaemia and 60-min reperfusion. IPC was induced as three cycles of 5-min global ischaemia-reperfusion, and provided significant reduction in infarct size (IS/AAR = 14 ± 2% vs control IS/AAR = 48 ± 3%, p
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