1. SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations.
- Author
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Matsson, Hans, Tammimies, Kristiina, Zucchelli, Marco, Anthoni, Heidi, Onkamo, Päivi, Nopola-Hemmi, Jaana, Lyytinen, Heikki, Leppanen, Paavo H. T., Neuhoff, Nina, Warnke, Andreas, Schulte-Körne, Gert, Schumacher, Johannes, Nöthen, Markus M., Kere, Juha, and Peyrard-Janvid, Myriam
- Subjects
DYSLEXIA ,GENES ,LEARNING disability genetics ,LINKAGE (Genetics) ,READING disability ,DEVELOPMENTAL disabilities - Abstract
Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota ( DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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