1. Protective effect of the orientin on noise-induced cognitive impairments in mice.
- Author
-
Wang, Shuting, Yu, Yinghua, Feng, Yan, Zou, Fang, Zhang, Xiaofei, Huang, Jie, Zhang, Yuyun, Zheng, Xian, Huang, Xu-Feng, Zhu, Yufu, and Liu, Yi
- Subjects
- *
FLAVONES , *COGNITION disorders , *OXIDATIVE stress , *PHYSIOLOGICAL effects of noise , *LABORATORY mice , *THERAPEUTICS , *PREVENTION - Abstract
There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noise-induced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF