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Your search keyword '"Benzodiazepines agonists"' showing total 2 results
Start Over Descriptor "Benzodiazepines agonists" Journal behavioural brain research
2 results on '"Benzodiazepines agonists"'

1. Effects of NOS inhibitors on the benzodiazepines-induced memory impairment of mice in the modified elevated plus-maze task.

Author

Orzelska J, Talarek S, Listos J, and Fidecka S

Subjects
Animals, Benzodiazepines agonists, Benzodiazepines antagonists & inhibitors, Diazepam agonists, Diazepam antagonists & inhibitors, Diazepam pharmacology, Dose-Response Relationship, Drug, Enzyme Inhibitors pharmacology, Flunitrazepam agonists, Flunitrazepam antagonists & inhibitors, Flunitrazepam pharmacology, Indazoles pharmacology, Male, Mice, NG-Nitroarginine Methyl Ester pharmacology, Retention, Psychology drug effects, Benzodiazepines pharmacology, Maze Learning drug effects, Memory Disorders chemically induced, Nitric Oxide Synthase antagonists & inhibitors
Abstract

The aim of the present study was to examine the effects of nitric oxide synthase (NOS) inhibitors on responses, elicited by benzodiazepines (BZs) in a modified elevated plus-maze task in mice. It was shown that acute doses of diazepam (DZ; 1 and 2 mg/kg) and flunitrazepam (FNZ; 0.05, 0.1 and 0.2 mg/kg) significantly increased the time of transfer latency (TL2) in a retention trial, thus confirming memory impairing effects of BZs. l-NAME (N(G)-nitro-l-arginine methyl ester; 200 mg/kg), a non-selective inhibitor of NOS, and 7-NI (7-nitroindazole; 40 mg/kg), a selective inhibitor of NOS, further intensified DZ-induced memory impairment. On the other hand, L-NAME (50, 100 and 200 mg/kg) and 7-NI (10, 20 and 40 mg/kg) prevented FNZ-induced memory compromising process. The results of this study indicated that suppressed NO synthesis enhanced DZ-induced but prevented FNZ-induced memory impairment. Taken together, these findings could suggest NO involvement in BZs-induced impairment of memory processes. The precise mechanism of these controversial effects, however, remains elusive., (Copyright © 2013 Elsevier B.V. All rights reserved.)

Published
2013
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2. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide.

Author

Clément Y, Prut L, Saurini F, Mineur YS, Le Guisquet AM, Védrine S, Andres C, Vodjdani G, and Belzung C

Subjects
Adaptation, Psychological drug effects, Adaptation, Psychological physiology, Animals, Benzodiazepines metabolism, Carrier Proteins genetics, Cerebral Cortex drug effects, Cerebral Cortex metabolism, Dose-Response Relationship, Drug, Gene Expression Regulation genetics, Haplotypes genetics, Hippocampus drug effects, Hippocampus metabolism, Male, Maze Learning drug effects, Membrane Proteins genetics, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Motor Activity drug effects, Motor Activity genetics, RNA, Messenger metabolism, Reaction Time drug effects, Reaction Time genetics, Rotarod Performance Test, Space Perception drug effects, Space Perception physiology, Behavior, Animal drug effects, Benzodiazepines agonists, Chlordiazepoxide, Gene Expression Regulation drug effects, Mutation genetics, Receptors, GABA-A genetics
Abstract

The gabra5 gene is associated with pharmacological properties (myorelaxant, amnesic, anxiolytic) of benzodiazepines. It is tightly located (0.5 cM) close to the pink-eyed dilution (p) locus which encodes for fur color on mouse chromosome 7. We tested the putative role of the gabra5 gene in pharmacological properties of the full non specific agonist chlordiazepoxide (CDP), using behavioral and molecular approaches in mutated p/p mice and wild type F2 from crosses between two multiple markers inbred strain ABP/Le and C57BL/6By strain. From our results, using rotarod, light-dark box, elevated maze and radial arm maze tests, we demonstrate that p/p mice are more sensitive than WT to the sensory motor, anxiolytic and amnesic effect of CDP. This is associated with the presence of a haplotypic block on the murine chromosome 7 and with an up regulation of gabra5 mRNAs in hippocampi of p/p F2 mice., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2012
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