1. Physical activity and neural correlates of aging: a combined TMS/fMRI study
- Author
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Todd M. Manini, Lauren Seeds, Anastasia Ford, Bruce Crosson, Zvinka Z. Zlatar, Andrew Bauer, Keith M. McGregor, Keith D. White, Stephanie Phan, Jeffrey A. Kleim, Erin Kleim, and Atchar Sudhyadhom
- Subjects
Adult ,Male ,medicine.medical_specialty ,Aging ,Adolescent ,medicine.medical_treatment ,Movement ,Physical fitness ,Physical exercise ,Audiology ,Motor Activity ,Brain mapping ,Article ,Behavioral Neuroscience ,Young Adult ,Surveys and Questionnaires ,medicine ,Image Processing, Computer-Assisted ,Reaction Time ,Aerobic exercise ,Humans ,Aged ,Aged, 80 and over ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Electromyography ,Brain ,Middle Aged ,Evoked Potentials, Motor ,Magnetic Resonance Imaging ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,Bacteria, Aerobic ,Oxygen ,medicine.anatomical_structure ,Area Under Curve ,Female ,Seasons ,Primary motor cortex ,business ,Functional magnetic resonance imaging ,Psychology ,Neuroscience ,Motor cortex ,Muscle Contraction - Abstract
Aerobic exercise has been suggested to ameliorate aging-related decline in humans. Recently, evidence has indicated chronological aging is associated with decreases in measures of interhemispheric inhibition during unimanual movements, but that such decreases may be mitigated by long-term physical fitness. The present study investigated measures of ipsilateral (right) primary motor cortex activity during right-hand movements using functional magnetic resonance imaging and transcranial magnetic stimulation (TMS). Healthy, right-handed participant groups were comprised of 12 sedentary older adults, 12 physically active older adults, and 12 young adults. Active older adults and younger adults evidenced longer ipsilateral silent periods (iSP) and less positive BOLD of ipsilateral motor cortex (iM1) as compared to sedentary older adults. Across groups, duration of iSP from TMS was inversely correlated with BOLD activity in iM1 during unimanual movement. These findings suggest that increased physical activity may have a role in decreasing aging-related losses of interhemispheric inhibition.
- Published
- 2011