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Highlights • Exposure to delayed rewards increased preference for larger-later rewards. • Exposure to immediate rewards decreased preference for larger-later rewards. • Changes in timing precision were not predictive of changes in choice. • More research is necessary to uncover the underlying mechanism for these effects. Abstract A relatively strong preference for smaller-sooner rewards (SSR) over larger-later rewards (LLR) is associated with a host of maladaptive behavioral patterns. As such, the clinical implications for increasing preference for LLR are profound. There is a growing body of literature that suggests extended exposure to delayed reward may increase preference for LLR in rats. However, questions remain about the underlying mechanism driving this effect and the extent to which extended exposure to immediate rewards may decrease LLR choice. In Experiment 1, we tested effects of a differential-reinforcement-of-low-rates schedule (DRL) to increase LLR choice using a pretest/posttest design with Wistar rats as subjects. We compared this group to a group of rats exposed to a differential-reinforcement-of-high-rates schedule (DRH). The DRH intervention has never been employed in this research context, but explicitly programs an immediate response-reinforcement requirement. In Experiment 2, we tested effects of an intervention with a delay longer than those used in the delay discounting pretest and posttest. No previous research has tested effects of an intervention delay this long, relative to the delay discounting task. We compared this group to a group exposed to a delay that was part of the delay discounting pretest and posttest and to a group exposed to a traditional no-delay, fixed-ratio (FR) 2 control intervention. In both experiments, we found that exposure to delayed rewards in the intervention phase significantly increased LLR choice relative to pretest performance. These findings replicate and extend a growing body of literature showing that delay exposure increases preference for LLR. We also found significant decreases in LLR choice from pretest to posttest in the DRH and no-delay intervention groups in Experiments 1 and 2, respectively. This is the first report of such an effect and has implications for understanding and interpreting effects of delay exposure training in past and future research. Our results also suggested no relationship between improved temporal tracking of reward and increases in LLR choice as a result of delay exposure training. [ABSTRACT FROM AUTHOR]

State-dependent valuation learning (SDVL) is a preference for stimuli associated with relative food deprivation over stimuli associated with relative satiety. Pigeons were exposed to experimental conditions designed to investigate SDVL and to test the hypothesis that obtained relative immediacy during training predicts choice during test probes. Energy states were manipulated using a procedure that has previously revealed SDVL in starlings and pigeons. In Experiment 1, pigeons preferred the stimulus associated with deprivation in the first choice probe session, but were indifferent in the second. Changes in choice were consistent with changes in obtained relative immediacy. In Experiment 2, training parameters were altered and SDVL did not occur. Obtained relative immediacy again predicted choice. Results of both experiments provide evidence that obtained relative immediacy may be an important contributing factor to the SDVL phenomenon. [ABSTRACT FROM AUTHOR]

• The CNTNAP2 gene is implicated in several neuropsychological disorders. • CNTNAP2 knockout rats and controls were compared on a temporal bisection task. • CNTNAP2 knockout rats exhibited less precise timing at the long cue durations. • Results have implications for understanding role of CNTNAP2 gene in timing. The CNTNAP2 gene has been implicated in several neuropsychological disorders, including autism spectrum disorder (ASD) and schizophrenia. The CNTNAP2 knockout (KO) rat model, rats without the CNTNAP2 gene, exhibits deficits in social interaction and increases in both repetitive and anxiety-like behaviors. However, deficits in time perception that may underlie several of the neuropsychological disorders implicated have not been investigated. The current study investigated timing in CNTNAP2 KO rats compared to control rats using a discrete-trial temporal bisection task. Results suggested deficits in the timing of relatively long durations in the CNTNAP2 KO rats. This finding is consistent with similar findings previously reported in humans diagnosed with ASD, and is promising for understanding the role that the CNTNAP2 gene may play in timing in certain neuropsychological disorders, and for developing targeted clinical therapies. [ABSTRACT FROM AUTHOR]