1. Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease.
- Author
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Cathcart P, Lucchesi W, Ottaviani S, De Giorgio A, Krell J, Stebbing J, and Castellano L
- Subjects
- Animals, Antineoplastic Agents, Hormonal pharmacology, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Drug Resistance, Neoplasm, Female, Humans, Male, Prostatic Neoplasms drug therapy, Prostatic Neoplasms genetics, RNA, Long Noncoding metabolism, Receptors, Cytoplasmic and Nuclear antagonists & inhibitors, Receptors, Cytoplasmic and Nuclear metabolism, Breast Neoplasms metabolism, Prostatic Neoplasms metabolism, RNA, Long Noncoding genetics, Receptors, Cytoplasmic and Nuclear genetics, Signal Transduction
- Abstract
Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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