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Objective:Surgical site infection (SSI) is one of the important factors leading to revision surgery after total knee arthroplasty (TKA). Nurses play an important role in the diagnosis of risky patients. This study aimed to determine factors leading to the development of SSI that required revision surgery after TKA.Methods:This study was a retrospective case-control study conducted on the causes of SSI requiring revision surgery after TKA in a large hospital. Sociodemographic and medical characteristics of randomly sampled patients with revision (n=77) and the control group (n=77) were compared. Descriptive statistics, chi-square test, independent samples t-test, multiple logistic regression were used for data analysis.Results:The mean age of the patients in the revision and control groups were 68.11±7.62 and 66.48±5.17, respectively. The mean body mass index (BMI) (37.49±5.22) and operative duration (58.24±17.20 min) of the patients in the revision group were significantly higher, while their preoperative (36.36±0.24 ºC), intraoperative (36.30±0.26 ºC), and postoperative (36.56±0.39 ºC) body temperatures were significantly lower (p