1. miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice.
- Author
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Qiao, Yu, Zhao, Yanli, Liu, Yan, Ma, Ning, Wang, Chuxuan, Zou, Jiaqi, Liu, Zhiyan, Zhou, Zhongqiu, Han, Dong, He, Jun, Sun, Qian, Liu, Yicong, Xu, Changqing, Du, Zhimin, and Huang, Hui
- Subjects
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DIABETIC cardiomyopathy , *APOPTOSIS , *MICRORNA genetics , *GENETIC regulation , *CELLULAR signal transduction , *LABORATORY mice - Abstract
Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomyopathy remains to be demonstrated. Our results show that miR-483-3p is upregulated in streptozotocin-induced diabetic mice, and cultured cardiomyocytes mimicking hyperglycemia. Overexpressing miR-483-3p in transgenic mice with diabetes mellitus (DM) exacerbated cardiomyocyte apoptosis by transcriptionally repressing insulin growth factor 1 (IGF1). Therefore, we have uncovered a novel signaling pathway, involving miR-483-3p-IGF1, that promotes myocardial cell apoptosis under high blood-glucose condition. Further, our study indicates that miR-483-3p could be a potential therapeutic target for managing diabetes-associated heart complications. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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