1. Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation.
- Author
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Li, Zheng Jun, Shin, Jung-Min, Choi, Dae-Kyoung, Lim, Seul Ki, Yoon, Tae-Jin, Lee, Young Ho, Sohn, Kyung-Cheol, Im, Myung, Lee, Young, Seo, Young-Joon, Kim, Chang Deok, and Lee, Jeung-Hoon
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CUCURBITACINS , *SKIN inflammation , *PSORIASIS , *KERATINOCYTES , *CELLULAR signal transduction - Abstract
Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-κB and STAT3 signaling pathway in human keratinocytes. In addition, keratinocyte proliferation was markedly inhibited by cucurbitacin B. The potential beneficial effect of cucurbitacin B on psoriasis was further validated in imiquimod-induced psoriasiform dermatitis of experimental animal. Topical application of cucurbitacin B resulted in significant reduction of epidermal hyperplasia and inflammatory cytokines production, and ameliorated the psoriatic symptom. Taken together, these results suggest that cucurbitacin B may be a potential candidate for the treatment of psoriasis. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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