1. miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin.
- Author
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Wang, Meng, Cai, Wen-Run, Meng, Ran, Chi, Jiang-Rui, Li, Yun-Rui, Chen, Ao-Xiang, Yu, Yue, and Cao, Xu-Chen
- Subjects
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MICRORNA genetics , *GENETICS of breast cancer , *GENE silencing , *CANCER invasiveness , *SURVIVIN (Protein) , *GENETIC overexpression - Abstract
Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions as a tumor suppressor in several types of human cancers. However, its role in breast cancer chemosensitivity have not been determined. In the present study, we demonstrated that overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity both in vitro and in vivo . Further study demonstrated that miR-485-5p directly targeted the 3′-untranslated region of survivin and overexpression of survivin overcomes the miR-485-5p induced effects on breast cancer. In conclusion, our study identified that miR-485-5p suppresses cancer progression and enhances the chemosensitivity by targeting survivin. Targeting survivin by miR-485-5p may provide a potential approach to reverse chemosensitivity in breast cancer cells. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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