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Start Over Author "Kibler, Karen" Journal biochemical & biophysical research communications
1 results on '"Kibler, Karen"'

1. Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Author

Löhr, Marianne, Kibler, Karen V., Zachary, Ian, Jeang, Kuan-Teh, and L. Selwood, David

Subjects
*HIV, *CHEMOKINES
Abstract

Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31–35 to anti-HIV-1 activity. [Copyright &y& Elsevier]

Published
2003
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