1. Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus
- Author
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Nie, Kun, Yu, Jian-Chun, Fu, Yu, Cheng, Hai-Yan, Chen, Fu-Yan, Qu, You, and Han, Jing-Xian
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PHYSIOLOGICAL aspects of aging , *PROTEIN kinases , *HIPPOCAMPUS (Brain) , *ALZHEIMER'S disease , *LABORATORY mice , *PHOSPHORYLATION , *MESSENGER RNA ,RISK factors of neurodegeneration - Abstract
Abstract: Aging is the greatest risk factor for neurodegenerative diseases such as Alzheimer’s disease (AD). Age-dependent alterations of cell signaling play an important role in the onset of AD. The serine/threonine kinase Akt is a critical cell signaling to neuronal survival. Using the senescence-accelerated mouse SAMP10, we investigated the effect of aging on AKT signaling in hippocampus tissue. During aging, the expression of Akt mRNA and protein remained stable. However, the constructive phosphorylation of AktSer473 displayed a continuous decrease after 6months in SAMP10. When compared with the control SAMR1, aged SAMP10 mice showed significant reduced phosphorylation of AktSer473. SAMP10 at the age of 6months showed obvious deterioration in performance of learning and memory tasks. Thus, the data reported here suggested a potential link between the age-related alteration of AktSer473 and the deterioration in performance of learning and memory tasks in SAMP10 mouse. [Copyright &y& Elsevier]
- Published
- 2009
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