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Start Over Author "Lepoivre M" Journal biochemical and biophysical research communications
6 results on '"Lepoivre M"'

6. Inactivation of ribonucleotide reductase by nitric oxide.

Author

Lepoivre M, Fieschi F, Coves J, Thelander L, and Fontecave M

Subjects
Animals, Cell Line, Cytosol enzymology, Electron Spin Resonance Spectroscopy, Glutathione analogs & derivatives, Glutathione pharmacology, Kinetics, Mammary Neoplasms, Experimental enzymology, Molsidomine analogs & derivatives, Molsidomine pharmacology, Nitroprusside pharmacology, Nitroso Compounds pharmacology, Oxyhemoglobins pharmacology, S-Nitrosoglutathione, Superoxide Dismutase pharmacology, Vasodilator Agents pharmacology, Xanthine Oxidase pharmacology, Nitric Oxide pharmacology, Ribonucleotide Reductases antagonists & inhibitors
Abstract

Ribonucleotide reductase has been demonstrated to be inhibited by NO synthase product(s). The experiments reported here show that nitric oxide generated from sodium nitroprusside, S-nitrosoglutathione and the sydnonimine SIN-1 inhibits ribonucleotide reductase activity present in cytosolic extracts of TA3 mammary tumor cells. Stable derivatives of these nitric oxide donors were either inactive or much less inhibitory. EPR experiments show that the tyrosyl radical of the small subunit of E. Coli or mammalian ribonucleotide reductase is efficiently scavenged by these NO donors.

Published
1991
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