1. Hypoxic glioblastoma release exosomal VEGF-A induce the permeability of blood-brain barrier.
- Author
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Zhao C, Wang H, Xiong C, and Liu Y
- Subjects
- Animals, Capillary Permeability physiology, Claudin-5 physiology, Exosomes physiology, Gene Knockdown Techniques, Humans, Male, Mice, Mice, Inbred ICR, Occludin physiology, Vascular Endothelial Growth Factor A antagonists & inhibitors, Vascular Endothelial Growth Factor A genetics, Blood-Brain Barrier physiopathology, Brain Neoplasms blood supply, Brain Neoplasms physiopathology, Glioblastoma blood supply, Glioblastoma physiopathology, Tumor Hypoxia physiology, Vascular Endothelial Growth Factor A physiology
- Abstract
Exosomes are nano-vesicles released by tumor cells to modulate extracellular environment. Accumulating evidence revealed that glioblastoma derived exosomes contain multiple pro-angiogenic factors to induce the proliferation of endothelial cells. Here, we investigated the role of GBM-derived exosomes in inducing the permeability of the blood-brain barrier. We found that VEGF-A was over-expressed in hypoxic GBM-derived exosomes, which enhance the permeability of a BBB in vitro model by interrupting the expression of claudin-5 and occludin. In vivo permeability assay showed hypoxic GBM-derived exosomes remained functional in the blood circulation and induced the permeability of BBB., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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