1. Mechanism of interferon action inhibition of vesicular stomatitis virus in human amnion U cells by cloned human leukocyte interferon
- Author
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Paul S. Masters and Charles E. Samuel
- Subjects
Transcription, Genetic ,viruses ,Biophysics ,Vesicular stomatitis Indiana virus ,Biology ,Virus Replication ,medicine.disease_cause ,Biochemistry ,Viral Proteins ,Interferon ,medicine ,Protein biosynthesis ,Humans ,Amnion ,Cloning, Molecular ,Molecular Biology ,Cells, Cultured ,Mutation ,Dose-Response Relationship, Drug ,Cell Biology ,biology.organism_classification ,Virology ,Molecular biology ,medicine.anatomical_structure ,Viral replication ,Vesicular stomatitis virus ,Interferon Type I ,RNA, Viral ,Interferon type I ,medicine.drug - Abstract
The effects of a subsaturating, long treatment (24 h) dose of a highly purified cloned subspecies of human leukocyte interferon (IFN-alpha A) on vesicular stomatitis virus (VSV) primary macromolecular synthesis in tsG41-infected human amnion U cells were examined. IFN-alpha A, under these conditions, was found to inhibit primary VSV protein synthesis ten-fold while producing no detectable effect on the amount or integrity of primary viral message transcripts. There was no selective reduction by IFN-alpha A of the VSV G or M proteins.
- Published
- 1984
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