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Your search keyword '"Shuto, Tsuyoshi"' showing total 15 results
Start Over Author "Shuto, Tsuyoshi" Journal biochemical and biophysical research communications
15 results on '"Shuto, Tsuyoshi"'

1. Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases

Author

Nohara, Hirofumi, primary, Nakashima, Ryunosuke, additional, Kamei, Shunsuke, additional, Fujikawa, Haruka, additional, Ueno-Shuto, Keiko, additional, Kawakami, Taisei, additional, Eto, Yuka, additional, Suico, Mary Ann, additional, Li, Jian-Dong, additional, Kai, Hirofumi, additional, and Shuto, Tsuyoshi, additional

Published
2020
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2. Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation

Author

Kamei, Shunsuke, primary, Maruta, Kasumi, additional, Fujikawa, Haruka, additional, Nohara, Hirofumi, additional, Ueno-Shuto, Keiko, additional, Tasaki, Yukihiro, additional, Nakashima, Ryunosuke, additional, Kawakami, Taisei, additional, Eto, Yuka, additional, Suico, Mary Ann, additional, Suzuki, Shingo, additional, Gruenert, Dieter C., additional, Li, Jian-Dong, additional, Kai, Hirofumi, additional, and Shuto, Tsuyoshi, additional

Published
2019
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3. Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK

Author

Watanabe, Kenji, primary, Shuto, Tsuyoshi, additional, Sato, Miki, additional, Onuki, Kouhei, additional, Mizunoe, Shota, additional, Suzuki, Shingo, additional, Sato, Takashi, additional, Koga, Tomoaki, additional, Suico, Mary Ann, additional, Kai, Hirofumi, additional, and Ikeda, Tsuyoshi, additional

Published
2011
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9. Calreticulin facilitates the cell surface expression of ABCG5/G8

Author

Okiyoneda, Tsukasa, primary, Kono, Taijun, additional, Niibori, Akiko, additional, Harada, Kazutsune, additional, Kusuhara, Hiroyuki, additional, Takada, Tappei, additional, Shuto, Tsuyoshi, additional, Suico, Mary Ann, additional, Sugiyama, Yuichi, additional, and Kai, Hirofumi, additional

Published
2006
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14. The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Author

Yoshida H, Takamura N, Shuto T, Ogata K, Tokunaga J, Kawai K, and Kai H

Subjects
3T3-L1 Cells, Adipocytes metabolism, Animals, Fatty Acids, Nonesterified metabolism, Flavanones chemistry, Flavanones isolation & purification, Flavonoids chemistry, Flavonoids isolation & purification, Hesperidin chemistry, Hesperidin isolation & purification, Insulin Resistance, Mice, Tumor Necrosis Factor-alpha metabolism, Adipocytes drug effects, Citrus chemistry, Flavanones pharmacology, Flavonoids pharmacology, Hesperidin pharmacology, Lipolysis drug effects, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract

Obese adipose tissue is characterized by an excessive production of inflammatory adipokines including tumor necrosis factor-alpha (TNF-alpha). TNF-alpha stimulates free fatty acid (FFA) secretion through adipocyte lipolysis, and increased plasma levels of FFA promote insulin resistance. In this report, we show that hesperetin and naringenin, two citrus flavonoids, inhibit TNF-alpha-stimulated FFA secretion from mouse adipocytes. These flavonoids block the TNF-alpha-induced activation of the NF-kappaB and ERK pathways. Moreover, hesperetin and naringenin prevent TNF-alpha from downregulating the transcription of two antilipolytic genes, perilipin and PDE3B. These effects are mediated through the inhibition of the ERK pathway. In contrast, the inhibition of the NF-kappaB pathway by hesperetin and naringenin suppresses the transcription of IL-6, which induces FFA secretion in an autocrine manner. Our results provide novel evidence that hesperetin and naringenin directly inhibit TNF-alpha-stimulated FFA secretion. These findings may be useful for ameliorating FFA-induced insulin resistance., (Copyright 2010 Elsevier Inc. All rights reserved.)

Published
2010
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15. SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor.

Author

Suico MA, Nakamura H, Lu Z, Saitoh H, Shuto T, Nakao M, and Kai H

Subjects
Amino Acid Substitution, Animals, Arginine genetics, Cell Line, DNA-Binding Proteins genetics, HeLa Cells, Humans, Lysine genetics, Lysine metabolism, Mice, SUMO-1 Protein metabolism, Small Ubiquitin-Related Modifier Proteins metabolism, Transcription Factors genetics, DNA-Binding Proteins antagonists & inhibitors, DNA-Binding Proteins metabolism, Down-Regulation physiology, SUMO-1 Protein physiology, Small Ubiquitin-Related Modifier Proteins physiology, Transcription Factors antagonists & inhibitors, Transcription Factors metabolism
Abstract

Myeloid elf-1-like factor (MEF) or Elf4 is an ETS protein known to regulate the basal expression of the anti-microbial peptides, lysozyme and human beta-defensin-2, in epithelial cells and activate the transcription of perforin in natural killer cells. The numerous target genes of MEF and its biological functions signify the importance of this Ets transcription factor. Here we show that MEF is modified by conjugation with SUMO-1/-2 (small ubiquitin-related modifier) both in mammalian cells and in Escherichia coli overexpressing human SUMO-1/-2. We identified by point mutation that lysine 657 of MEF is the site for sumoylation. This modification down-regulated MEF activity on lysozyme and perforin promoters, and decreased the lysozyme mRNA expression. Chromatin immuno-precipitation analysis revealed that SUMO-conjugation diminished the recruitment of MEF to the lysozyme promoter, which partly explains the down-regulation of MEF activity by SUMO. These findings contribute to our understanding of the regulation of the ETS factor MEF.

Published
2006
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