1. Regulation of Tim-3 function by binding to phosphatidylserine.
- Author
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Kane, Lawrence P.
- Subjects
- *
HEPATITIS A virus cellular receptors , *T cells , *CYTOTOXIC T cells , *MYELOID cells , *MEMBRANE proteins , *CD8 antigen , *INTERLEUKIN-9 , *ANNEXINS - Abstract
Tim-3 is a transmembrane protein that is highly expressed on subsets of chronically stimulated CD4+ helper and CD8+ cytotoxic T cells, with more transient expression during acute activation and infection. Tim-3 is also constitutively expressed by multiple types of myeloid cells. Like other TIM family members, Tim-3 can bind to phosphatidylserine displayed by apoptotic cells, and this interaction has been shown to mediate uptake of such cells by dendritic cells and cross-presentation of antigens to CD8+ T cells. In contrast, how the recognition of PS by Tim-3 might regulate the function of Tim- 3+ T cells is not known. In their recent paper, Lemmon and colleagues demonstrate for the first time that recognition of PS by Tim-3 leads to enhanced T cell activation. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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