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1. Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.

Author

Williamson DH, Ilic V, Tordoff AF, and Ellington EV

Subjects
Animals, Butyrates metabolism, Drug Interactions, Female, Glucose biosynthesis, In Vitro Techniques, Lactates biosynthesis, Liver cytology, Liver drug effects, Rats, Glucagon pharmacology, Ketone Bodies biosynthesis, Liver metabolism, Oleic Acids metabolism, Vasopressins pharmacology
Abstract

Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.

Published
1980
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