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Start Over Author "D.M. Turnbull" Journal biochemical society transactions
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1. Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Author

K.J. Krishnan, A.K. Reeve, and D.M. Turnbull

Subjects
MITOCHONDRIAL DNA, GENETIC mutation, CELL death, MITOCHONDRIAL pathology, NEURODEGENERATION, CELLULAR pathology
Abstract

A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2007
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