1. Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease.
- Author
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Maltas J, Reed H, Porter A, and Malliri A
- Subjects
- Animals, Cell Adhesion, Cell Movement, Cell Proliferation, Cell Survival, Humans, Immune System, Nervous System Diseases metabolism, Neurons metabolism, Protein Domains, RNA Processing, Post-Transcriptional, Signal Transduction, rac1 GTP-Binding Protein metabolism, Guanine Nucleotide Exchange Factors metabolism, Neoplasms metabolism, T-Lymphoma Invasion and Metastasis-inducing Protein 1 metabolism, rac GTP-Binding Proteins metabolism
- Abstract
The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease., (© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.)
- Published
- 2020
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