1. The role of p63 in epidermal morphogenesis and neoplasia.
- Author
-
McDade SS and McCance DJ
- Subjects
- Alternative Splicing, Animals, Humans, Mice, Protein Isoforms genetics, Trans-Activators genetics, Transcription Factors, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Protein p53 metabolism, Tumor Suppressor Proteins genetics, Epidermis anatomy & histology, Epidermis embryology, Epidermis growth & development, Morphogenesis, Protein Isoforms metabolism, Skin Neoplasms metabolism, Trans-Activators metabolism, Tumor Suppressor Proteins metabolism
- Abstract
The p53 family of transcription factors is made up of p53, p63 and p73, which share significant structural homology. In particular, transcriptional complexity and the expression of multiple protein isoforms are an emergent trait of all family members. p63 is the evolutionarily eldest member of the p53 family and the various isoforms have critical roles in the development of stratifying epithelia. Recent results have uncovered additional splice variants, adding to the complexity of the transcriptional architecture of p63. These observations and the emerging extensive interplay between p63 and p53 in development, proliferation and differentiation underline the importance of considering all isoforms and family members in studies of the function of p53 family members.
- Published
- 2010
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