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Your search keyword '"Cohen, Joshua M."' showing total 2 results
Start Over Author "Cohen, Joshua M." Publication Year Range Last 50 years Journal biochemistry
2 results on '"Cohen, Joshua M."'

1. Push and pull of tropomyosin' opposite effects on myosin attachment to actin. A chimeric tropomyosin host-guest study

Author

Ali, Laith F., Cohen, Joshua M., and Tobacman, Larry S.

Subjects
Chimeras (Organisms) -- Analysis, Brewer's yeast -- Physiological aspects, Yeast fungi -- Genetic aspects, Yeast fungi -- Physiological aspects, Biological sciences, Chemistry
Abstract

Chimeric tropomyosins are generated in which 38-residue muscle tropomyosin segments have replaced a natural duplication within Saccharomyces cerevisiae tropomyosin TPM1. Myosin S1-ADP binding to actin is strengthened by substitution of chimera 3 tropomyosin for wild-type TPM1 and a yeast tropomysin is induced to mimic the activating behavior or mammalian tropomyosin by inserting a mammalian tropomyosin sequence.

Published
2010

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