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Your search keyword '"Bae, Sung-Hun"' showing total 4 results
Start Over Author "Bae, Sung-Hun" Journal biochemistry
4 results on '"Bae, Sung-Hun"'

1. Prion proteins with pathogenic and protective mutations show similar structure and dynamics

Author

Bae, Sung-Hun, Legname, Giuseppe, Serban, Ana, Prusiner, Stanley B., Wright, Peter E., and Dyson, H. Jane

Subjects
Gene mutations -- Analysis, Prions -- Structure, Prions -- Chemical properties, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

A study was conducted to examine the dynamics of the pathogenic mutants (P101L and H186R), protective mutants (Q167R and Q218K), and wild-type mouse PrP(89?230) at pH 5.5 and 3.5. Findings suggested the possibility that the pathogenic or dominant negative mutations exert their effects on non-native intermediate.

Published
2009

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