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Start Over Author "Das, Rhiju" Journal biochemistry
6 results on '"Das, Rhiju"'

3. A mutate-and-map strategy for inferring base pairs in structured nucleic acids: proof of concept on a DNA/RNA helix

Author

Kladwang, Wipapat and Das, Rhiju

Subjects
DNA -- Structure, DNA -- Chemical properties, Gene mutations -- Analysis, Methyl groups -- Chemical properties, Sulfates -- Chemical properties, Biological sciences, Chemistry
Abstract

High-throughput dimethyl sulfate accessibility data for a chimeric DNA/RNA system is described in which every possible sequence variation and deletion in a 20 bp region is prepared and tested. The results have shown the feasibility of rapid base pair inference in larger and more complex nucleic acid systems with unknown structure.

Published
2010

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