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Start Over Author "Krystal, Mark R." Journal biochemistry
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1. The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors

Author

Langley, David R., Samanta, Himadri K., Lin, Zeyu, Walker, Michael A., Krystal, Mark R., and Dicker, Ira B.

Subjects
Adenosine -- Chemical properties, Deoxyribose -- Chemical properties, HIV (Viruses) -- Composition, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

The kinetics of binding of a specific HIV strand transfer inhibitor to integrase variants assembled with systematic changes to the terminal 3' adenosine is described. The results indicated that the terminal deoxyribose play a critical role to retard the rate of inhibitor dissociation, either by sterically blocking inhibitor egress or by a direct interaction with the bound inhibitor.

Published
2008

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