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Your search keyword '"Meiler, Jens"' showing total 15 results
Start Over Author "Meiler, Jens" Journal biochemistry
15 results on '"Meiler, Jens"'

2. Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

Author

Schoeder, Clara T., primary, Schmitz, Samuel, additional, Adolf-Bryfogle, Jared, additional, Sevy, Alexander M., additional, Finn, Jessica A., additional, Sauer, Marion F., additional, Bozhanova, Nina G., additional, Mueller, Benjamin K., additional, Sangha, Amandeep K., additional, Bonet, Jaume, additional, Sheehan, Jonathan H., additional, Kuenze, Georg, additional, Marlow, Brennica, additional, Smith, Shannon T., additional, Woods, Hope, additional, Bender, Brian J., additional, Martina, Cristina E., additional, del Alamo, Diego, additional, Kodali, Pranav, additional, Gulsevin, Alican, additional, Schief, William R., additional, Correia, Bruno E., additional, Crowe, James E., additional, Meiler, Jens, additional, and Moretti, Rocco, additional

Published
2021
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3. Practically useful: what the ROSETTA protein modeling suite can do for you

Author

Kaufmann, Kristian W., Lemmon, Gordon H., DeLuca, Samuel L., Sheehan, Jonathan H., and Meiler, Jens

Subjects
DNA -- Structure, DNA -- Chemical properties, Electron paramagnetic resonance spectroscopy -- Usage, Nuclear magnetic resonance spectroscopy -- Usage, X-ray crystallography -- Usage, Proteins -- Structure, Proteins -- Analysis, Biological sciences, Chemistry
Abstract

The ROSETTA method which was originally developed for de novo protein structure prediction reviewed to understand its application for biochemical and biomedicinal studies. ROSETTA method could be used to accurately design a novel protein structure, predict the structure of protein-protein complexes, design altered specificity protein-protein and protein-DNA interactions, and stabilize proteins and protein complexes.

Published
2010

4. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel

Author

Congbao Kang, Changlin Tian, Sonnichsen, Frank D., Smith, Jarrod A., Meiler, Jens, George, Alfred L., Jr., Vanoye, Carlos G., Hak Jun Kim, and Sanders, Charles R.

Subjects
Potassium channels -- Structure, Membrane proteins -- Structure, Molecular structure -- Research, Biological sciences, Chemistry
Abstract

The detailed studies and three-dimensional structure of KCNE1, a single-span membrane protein that modulates the voltage-gated potassium channel KCNQ1 by slowing activation and enhancing channel conductance to generate the slow delayed rectifier current, crucial for the repolarization phase of the cardiac action potential are presented. The KCNE1-KCNQ1 model might be used to formulate testable hypotheses of the molecular bases of disease phenotypes associated with the dozens of known inherited mutations in KCNE1 and KCNQ1.

Published
2008

5. Structural models for the KCNQ1 voltage-gated potassium channel

Author

Smith, Jarrod A., Vanoye, Carlos A., George, Alfred L., Jr., Meiler, Jens, and Sanders, Charles R.

Subjects
Potassium channels -- Research, Potassium channels -- Electric properties, Mutation (Biology) -- Research, Voltage -- Analysis, Biological sciences, Chemistry
Abstract

Three-dimensional models are developed for both the open and closed states of human voltage-gated potassium channel KCNQ1 in order to facilitate structurally based hypotheses regarding mutation-phenotype relationships. The gain-of-function mutation sites are localized at the interface between S1 in the voltage-sensor domain of one subunit and the S5 and P-helix segments of the pore domain of another subunit.

Published
2007

7. Protocols for Molecular Modeling with Rosetta3 and RosettaScripts

Author

Bender, Brian J., primary, Cisneros, Alberto, additional, Duran, Amanda M., additional, Finn, Jessica A., additional, Fu, Darwin, additional, Lokits, Alyssa D., additional, Mueller, Benjamin K., additional, Sangha, Amandeep K., additional, Sauer, Marion F., additional, Sevy, Alexander M., additional, Sliwoski, Gregory, additional, Sheehan, Jonathan H., additional, DiMaio, Frank, additional, Meiler, Jens, additional, and Moretti, Rocco, additional

Published
2016
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