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Start Over Author "Melville, Chris R." Journal biochemistry
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1. Reassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds

Author

Melville, Chris R., Green, Edward L., Sanders-Loehr, Joann, and Klinman, Judith P.

Subjects
Biochemistry -- Research, Binding sites (Biochemistry) -- Physiological aspects, Metalloenzymes -- Physiological aspects, Arthritis -- Research, Wilson's disease -- Research, Antiarthritic agents -- Research, Biological sciences, Chemistry
Abstract

The active site quino-cofactor that has been proposed in the Aspergillus niger amine oxidase AO-I has been reassessed from properties of model compounds. The name 'catalytic chelator' is given to inhibitors that promote the release of the active-site zinc of ZnCPD. The antiarthritis drug D-penicillamine, D-PEN, differs from D-Cys by the presence of two methyl groups on the beta carbon. It inhibits ZnCPD by promoting the release. A possible D-PEN mechanism in arthritis and Wilson's disease is suggested. Complications in use of D-PEN may be partially explained

Published
2000

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