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1. Identification of an inhibitor of microtubule assembly present in juvenile brain which displays a novel mechanism of action involving suppression of self-nucleation.

Author

Surridge CD and Burns RG

Subjects
Ammonium Sulfate, Animals, Brain growth & development, Cattle, Chemical Precipitation, Chickens, Kinetics, Microtubule Proteins metabolism, Microtubules ultrastructure, Brain ultrastructure, Brain Chemistry, Microtubule Proteins antagonists & inhibitors, Microtubules physiology
Abstract

An inhibitor of microtubule assembly has been identified and partially purified from microtubule-depleted brain extracts from day-old chicks and 4-month-old calf. This inhibitor suppresses the self-nucleation of microtubules in vitro with minimal effect upon the final extent of assembly. It may have a developmental role in vivo as it is not detected in adult brain from either cattle or rabbit.

Published
1991
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