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Your search keyword '"Possmayer, Fred"' showing total 5 results
Start Over Author "Possmayer, Fred" Journal biochemistry
5 results on '"Possmayer, Fred"'

1. Modification of tryptophan and methionine residues is implicated in the oxidative inactivation of surfactant protein

Author

Manzanares, Dahis, Rodriguez-Capote, Karina, Liu, Suya, Haines, Thomas, Ramos, Yudith, Lin Zhao, Doherty-Kirby, Amanda, Lajoie, Gilles, and Possmayer, Fred

Subjects
Methionine -- Structure, Methionine -- Chemical properties, Tryptophan -- Chemical properties, Tryptophan -- Structure, Surface active agents -- Structure, Surface active agents -- Chemical properties, Biological sciences, Chemistry
Abstract

Exposing bovine lipid extract surfactant (BLES), a clinical surfactant to reactive oxygen species (ROS) alters surfactant protein B (SP-B). ROS treatment of BLES clinical surfactant results in delayed absorption and an impairment of the ability to attain low surface tensions during film compression.

Published
2007

2. Three-dimensional structure of rat surfactant protein A trimers in association with phospholipid monolayers

Author

Palaniyar, Nades, McCormack, Francis X., Possmayer, Fred, and Harauz, George

Subjects
Rats -- Physiological aspects, Phospholipids -- Physiological aspects, Proteins -- Physiological aspects, Pulmonary surfactant -- Physiological aspects, Biological sciences, Chemistry
Abstract

Rat surfactant protein A (SP-A) trimers in association with phospholipid monolayers have been analyzed to determine their three-dimensional structure. The glycosylation site of SP-A was at the side of each subunit, which would suggest that the covalently linked carbohydrate moiety likely is in the spaces between the adjacent globular domains, which would not sterically interfere with ligand binding.

Published
2000

3. Intrinsic structural and functional determinants within the amino acid sequence of mature pulmonary surfactant protein SP-

Author

Serrano, Alicia G., Cruz, Antonio, Rodriguez-Capote, Karina, Possmayer, Fred, and Perez-Gil, Jesus

Subjects
Amino acids -- Research, Circular dichroism -- Spectra, Polypeptides -- Research, Polypeptides -- Structure, Biological sciences, Chemistry
Abstract

The study explored the inherent structural and functional determinants within the amino acid sequence of mature surfactant protein SP-B, porcine SP-B. It concluded that SP-B-like polypeptides lacing disulfides could still be potentially good mimics of native disulfide-linked SP-B.

Published
2005

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